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【产品介绍】Alpha-fetoprotein (AFP) is a serum
glycoprotein protein produced in the liver o r yolk sac
of fetal staged mammals. AFP synthesis is minimal
after birth a n d trace amount is expressed in the
adult liver (1). AFP gene expression is regulated by
the interactions between steroid h o r mone recept
o r s a n d transcriptional fact o r s in separate
signal transduction pathways (2). AFP functions as a
binding a n d transp o r ting lig a n d a n d cell
growth regulat o r . Elevated expression level of AFP
has been implicated in col o r ectal, ovarian,
pancreatic, testicular, a n d certain liver cancers.
High level of AFP is also seen some diseases, such
as hepatitis a n d colitis. AFP is used as a
screening marker f o r fetal abn o r malities in
pregnant women, such as Down syndrome. Recently,
AFP has been introduced as an anti-cancer drug-lig
a n d carrier, transp o r ting drugs to target
tum o r cells, increasing anti-tum o r efficiency (3).
WB: 1:50,000
IHC: 1:100-250
A. Western blot analysis on HepG2 cell lysate of
using anti-AFP (C-term) Rabbit Polyclonal (cat. # 1757-1), dilution 1:50,000
B. Immunohistochemical analysis of paraffin-embedded
human fetal liver using anti-AFP Rab pAb (cat. #1757-1).
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