质量标准: |
【产品介绍】Alpha-fetoprotein (AFP) is a serum glycoprotein protein produced in the liver o r yolk sac of fetal staged mammals. AFP synthesis is minimal after birth a n d trace amount is expressed in the adult liver (1). AFP gene expression is regulated by the interactions between steroid h o r mone recept o r s a n d transcriptional fact o r s in separate signal transduction pathways (2). AFP functions as a binding a n d transp o r ting lig a n d a n d cell growth regulat o r . Elevated expression level of AFP has been implicated in col o r ectal, ovarian, pancreatic, testicular, a n d certain liver cancers. High level of AFP is also seen some diseases, such as hepatitis a n d colitis. AFP is used as a screening marker f o r fetal abn o r malities in pregnant women, such as Down syndrome. Recently, AFP has been introduced as an anti-cancer drug-lig a n d carrier, transp o r ting drugs to target tum o r cells, increasing anti-tum o r efficiency (3). WB: 1:50,000 IHC: 1:100-250
A. Western blot analysis on HepG2 cell lysate of using anti-AFP (C-term) Rabbit Polyclonal (cat. # 1757-1), dilution 1:50,000 B. Immunohistochemical analysis of paraffin-embedded human fetal liver using anti-AFP Rab pAb (cat. #1757-1).
|