【产品介绍】Arginase catalyzes the hydrolysis of arginine
to ornithine and urea. At least two isoforms of
mammalian arginase exist (types I and II) which differ
in their tissue distribution, subcellular
localization, immunologic crossreactivity and
physiologic function. The type I isoform ARG1 is a
cytosolic enzyme and expressed predominantly in the liver
as a component of the urea cycle. Inherited deficiency
of this enzyme results in argininemia, an
autosomal recessive disorder characterized by
hyperammonemia (1).
Recommended Applications
WB, IHC, ICC, IP
Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000
IHC: 1:250 - 500
ICC: 1:50 - 100
IP: 1:10 - 100
Species Reactivity * Human *Species cross-reactivity is based on WB analysis. Products Data
Western blot analysis on (A) fetal liver and (B) fetal
lung lysates using anti-ARG1 RabMAb (cat. #5222-1). Immunohistochemical analysis of paraffin-embedded
human hepatocellular carcinoma tissue using anti-ARG1
RabMAb (cat. #5222-1). Specificity A synthetic peptide corresponding to residues in human
ARG1 was used as an immunogen.
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