【产品介绍】DOCK2 is a hematopoietic cell-specific
CDM family protein that is indispensable for
lymphocyte chemotaxis (1). DOCK2 plays a critical role
in lymphocyte homing and immunological synapse formation
by regulating the actin cytoskeleton. It has been shown
that DOCK2 deficiency enables long-term survival of
cardiac allografts across a complete mismatch of the
major histocompatibility complex molecules. DOCK2
is critical for CD28-mediated Rac activation and is
required for the full activation of alloreactive T cells (2).
Recommended Applications
WB, IHC
Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000
IHC: 1:50 - 100
Species Reactivity * Human *Species cross-reactivity is based on WB analysis. Products Data
Western blot analysis on (A) Jurkat and (B) Raji
cell lysates using anti-DOCK2 RabMAb (cat. #5351-1). Immunohistochemical analysis of paraffin-embedded human
lung tissue using anti-DOCK2 RabMAb (cat. #5351-1).
Note. Positive staining of peripheral lymphocytes Specificity A synthetic peptide corresponding to residues near
the C-terminus of human DOCK2 was used as an immunogen. |
沪公网安备 31012002003054号
