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生化科研试剂 >> 抗体产品 >> 一抗 |
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Gelsolin Rabbit Antibody Rabbit Monoclonal IgG |
别 名: |
Actin-depolymerizing fact o r , ADF, Brevin, AGEL |
货号 |
品名 |
规格 |
包装 |
单价 |
货期 |
库存 |
1227177831 |
Gelsolin Rabbit Antibody |
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100ul |
询价 |
现货 |
3天 |
提示信息:偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体,下单前请联系客服。 |
性 状: |
【反应特异性】Human 【克隆 ID】EP1940Y 【用途】WB , IHC 【抗原分子量】90 kDa |
质量标准: |
【产品介绍】Gelsolin is a large a n d complex actin-binding protein that belongs to actin-severing gelsolin/villin super family. Gelsolin is a regulat o r of actin filament assembly a n d disassembly a n d consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens a n d exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, a n d S3 sites. Gelsolin is involved in podosome f o r mation a n d has been linked to inhibition of apoptosis by preventing release of cytochrome C (2). WB: 1:1000 5000 IHC: 1:100-250
A. Western blot analysis on NIH 3T3 cell lysate using anti-Gelsolin RabMAb (cat. #2097-1), 1:5000 dilution.
B. Immunohistochemical analysis of paraffin-embedded human tonsils using anti-Gelsolin RabMAb (cat# 2097-1) |
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