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| 生化科研试剂 >> 抗体产品 >> 一抗 |
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Gelsolin Rabbit Antibody
Rabbit Monoclonal IgG |
| 别 名： |
Actin-depolymerizing fact o r , ADF, Brevin, AGEL |
| 货号 |
品名 |
规格 |
包装 |
单价 |
货期 |
库存 |
| 1227177831 |
Gelsolin Rabbit Antibody |
|
100ul |
询价 |
现货 |
3天 |
| 提示信息：偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。 |
| 性 状： |
【反应特异性】Human
【克隆 ID】EP1940Y
【用途】WB , IHC
【抗原分子量】90 kDa |
| 质量标准： |
【产品介绍】Gelsolin is a large a n d complex
actin-binding protein that belongs to
actin-severing gelsolin/villin super family. Gelsolin is
a regulat o r of actin filament assembly a n d disassembly
a n d consists of six homologous subdomains (S1-S6).
When C-terminal tail (S6) is bound to calcium ion,
it straightens a n d exposes actin binding sites located
on S2s helices, leading to Gelsolin actin-serving
activity (1). Gelsolin is inhibited by
phosphatidylinositol (4,5)-bisphosphate (PIP2), where
PIP2 will bind to S1, S2, a n d S3 sites. Gelsolin
is involved in podosome f o r mation a n d has been
linked to inhibition of apoptosis by preventing release
of cytochrome C (2).
WB: 1:1000 5000
IHC: 1:100-250
A. Western blot analysis on NIH 3T3 cell lysate
using anti-Gelsolin RabMAb (cat. #2097-1), 1:5000 dilution.
B. Immunohistochemical analysis of paraffin-embedded
human tonsils using anti-Gelsolin RabMAb (cat# 2097-1) |
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